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Through its activation of nAchRs nicotine also indirectly activates dopaminergic and glutamatergic receptors and systems 47,48

Researchers looked at cancer-causing cell damage from nicotine versions of e-cigs as well as the supposedly nicotine-free versions and found that although the full nicotine stuff is way worse, even a less concentrated exposure to nicotine in the vapor is enough to cause cell damage.

Acute effects of nicotine-free and flavour-free electronic cigarette use on lung functions in healthy and asthmatic individuals